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Catalogue No. CR0026
Product Name Raltegravir
CAS No. 518048-05-0
Purity 98%
Molecular Formula C20H21FN6O5
Molecular Weight 444.42
Incki Key CZFFBEXEKNGXKS-UHFFFAOYSA-N
Quantity Price($)
100mg 38.00 Place The Order
1g 135.00 Place The Order
Product Documents
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Synonym:

MK-0518; Isentress

Application:

A potent integrase strand transfer inhibitor for (PFV) IN

Description

Raltegravir is a potent HIV-1 integrase inhibitor. Raltegravir sensitizes S217Q PFV IN to the same extent as the WT enzyme. Raltegravir is potently active against HIV-1 in vitro. Raltegravir is also active against HIV-2 in CEMx174 cells. Raltegravir weakly inhibits hepatic cytochrome P450 activity. Raltegravir effectively attenuates viral replication. Raltegravir efficiently inhibits SIVmac251 replication in acutely infected human lymphoid CD4+ T-cell lines MT-4 and CEMx174.

Technical Information

Appearance:

Crystalline powder

Physical State:

Solid

Solubility:

Soluble in water (<1 mg/ml at 25 °C), DMSO (88 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

Storage:

Store at -20° C

IC50:

S217Q PFV: IC50 = 40 nM; WY: IC50 = 90 nM

Safety and Reference Information

PubChem CID:

54671008

 

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