| Catalogue No. | CR0026 |
|---|---|
| Product Name | Raltegravir |
| CAS No. | 518048-05-0 |
| Purity | 98% |
| Molecular Formula | C20H21FN6O5 |
| Molecular Weight | 444.42 |
| Incki Key | CZFFBEXEKNGXKS-UHFFFAOYSA-N |
| Quantity | Price($) | |
|---|---|---|
| 100mg | 38.00 | Place The Order |
| 1g | 135.00 | Place The Order |
| Product Documents |
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No Product Documents
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Synonym: |
MK-0518; Isentress |
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Application: |
A potent integrase strand transfer inhibitor for (PFV) IN |
Description
Raltegravir is a potent HIV-1 integrase inhibitor. Raltegravir sensitizes S217Q PFV IN to the same extent as the WT enzyme. Raltegravir is potently active against HIV-1 in vitro. Raltegravir is also active against HIV-2 in CEMx174 cells. Raltegravir weakly inhibits hepatic cytochrome P450 activity. Raltegravir effectively attenuates viral replication. Raltegravir efficiently inhibits SIVmac251 replication in acutely infected human lymphoid CD4+ T-cell lines MT-4 and CEMx174.
Technical Information
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Appearance: |
Crystalline powder |
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Physical State: |
Solid |
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Solubility: |
Soluble in water (<1 mg/ml at 25 °C), DMSO (88 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
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Storage: |
Store at -20° C |
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IC50: |
S217Q PFV: IC50 = 40 nM; WY: IC50 = 90 nM |
Safety and Reference Information
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PubChem CID: |
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